CVAC System Clinical Studies

Evidence at a Glance

The CVAC System is supported by clinical evidence, including 9 peer-review publications and 45+ scientific abstracts across randomized controlled trials, prospective studies, real-world evaluations, and comparative analyses, assessing safety, effectiveness, stone clearance, intrarenal pressure, and clinical outcomes.

2

Randomized Controlled Trials

1

Prospective Study

4

Comparative Studies

6

Safety and Intrarenal Pressure Studies

3

Real-World Studies

Randomized Controlled Trial (RCT)

Residual Stone Volume Predicts Health Care Consumption and Stone Events: Analysis of Two-Year Results of the ASPIRE Study.

Matlaga BR, Mueller TJ, Johnson B, et al. Journal of Endourology. 2026;0(0). doi:10.1177/08927790261420565

A Prospective, Randomized, Noninferiority Study to Evaluate the Safety and Effectiveness of Steerable Ureteroscopic Renal Evacuation Compared with Standard Ureteroscopy: 30-Day Results of the ASPIRE Study.

Matlaga BR, Mueller TJ, Johnson B, et al. Journal of Endourology. 2025;39(1):10-18. doi:https://doi.org/10.1089/end.2024.0602

Prospective Trial

A Prospective Study of Steerable Ureteroscopic Renal Evacuation Using the Second-Generation CVAC® Aspiration System: Results from the CLEARANCE Study.

Eisner BH, Pathak N, Sabnis R, et al. Journal of Endourology. 2026;0(0). doi:10.1177/08927790261415603

Real-World

Is 3 cm the upper limit of stone size for effective steerable ureteroscopic renal stone evacuation?

Chen WJ, Camargo Maluf F, Jarvis H, et al. World Journal of Urrology. 2026;44(1):208. doi:https://doi.org/10.1007/s00345-026-06310-7

First in-vivo multicenter experience with the novel CVAC 2.0 ureteroscope with simultaneous irrigation and aspiration functionality.

Ballantyne CC, Foss HE, Cabo JJ, et al. World Journal of Urology. 2025;43(1). doi:https://doi.org/10.1007/s00345-025-05912-x

Early Experience of Steerable Ureteroscopic Renal Evacuation (S.U.R.E.) with CVAC® System Next Gen 2.0 with Quantitative Computed Tomography Stone Analysis Software.

Griffiths L, Girgiss J, He C, et al. Journal of Urology. 2025;213(5S). doi:https://doi.org/10.1097/01.ju.0001109904.25944.a0.10

Real-World Experience with CVAC 2.0 For Steerable Ureteroscopic Renal Evacuation in a Large, Multi-Site Academic Institution.

Klyde DM, Aro T, Okeke Z, Hoenig DM, Rai A, Swinoker J. Journal of Urology. 2025;213(5S0):36. doi:https://doi.org/10.1097/01.JU.0001109712.09934.41.06

A Retrospective Analysis of the 2nd Generation CVAC Ureteroscope’s Stone Clearance: Our Initial Experience.

Cook BP, Hietanen C, Cummings S, et al. Journal of Urology. 2025;213(5S0):424. doi:https://doi.org/10.1097/01.JU.0001109856.11315.1d.19

Steerable Ureteroscopic Renal Evacuation (SURE) for Large Renal Stones: A Multi-Institutional Center Study.

Stern KL, Borgert BJ, Wolf JS. Journal of Endourology. 2023;37(11):1179-1183. doi:https://doi.org/10.1089/end.2023.0424

Safety

Impact of Steerable Ureteroscopic Renal Evacuation (SURE) Using CVAC on Intrarenal Pressure.

Eberrios S, Ekatz J, Finegan JL, et al. Journal of Urology. 2025;213(5S). doi:https://doi.org/10.1097/01.ju.0001109712.09934.41.09

CVAC System Maintains Consistently Low Intrarenal Pressure Independent of Ureteropelvic Junction Compliance Via Continuous Fluid Outflow.

Eisner BH, Serge M, Jenkins T. Journal of Urology. 2025;213(5S). doi:https://doi.org/10.1097/01.ju.0001109856.11315.1d.05

Initial Safety and Feasibility of Steerable Ureteroscopic Renal Evacuation: A Novel Approach for the Treatment of Urolithiasis.

Sur RL, Agrawal S, Eisner BH, et al. Journal of Endourology. 2022;36(9):1161-1167. doi:https://doi.org/10.1089/end.2021.0759

Comparative

Prospective, Real-World Evaluation of CVAC 2.0 In-Scope Aspiration System Compared with Flexible and Navigable Ureteral Access Sheath for High-Volume Stone Disease.

Cabo JJS, Ballantyne CC, Edmonds VS, Humphreys MR, Stern KL. Journal of Endourology. 2025;39(12):1215-1221. doi:https://doi.org/10.1177/08927790251387343

CVAC System Superior to Direct-In-Scope Suction Across Range of Stone Sizes in a Direct In Vitro Comparison of Stone Fragment Aspiration.

Johnson B, Palma-Zamora I. EAU25 – 40th Annual EAU Congress, Abstract Session 20. Madrid, Spain. March 2025. https://urosource.uroweb.org/resource-centres/EAU25/262832/abstract

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